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PresentationsBiophysics of organisms as open nonequilibrium systems and the nature of changes in statistical entropyV.A. Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences, Moscow, Russia. nech99@mail.ru 1Institute of Cell Biophysics of the Russian Academy of Sciences - FITZ "Pushchinsky Scientific Center for Biological Research of the Russian Academy of Sciences", Pushchino, Moscow Region, Russia 2Federal Research Center "Informatics and Management" of the Russian Academy of Sciences, Moscow, Russia The concept of entropy is used to characterize biological structures as open systems: both equilibrium and nonequilibrium. Schrödinger's ideas [1] about the possibility of stationary maintenance of a biostructure due to a constant influx of negentropy are being developed, and the concept of statistical entropy in relation to biological organisms is discussed in detail [2, 3]. The use of statistical and kinetic methods made it possible to construct a number of models of biological systems and study some general properties of such systems, including aspects of degradation (aging), see [4-5]. The model of epithelial aging is discussed in detail. The development of these models can be seen in several directions. One possibility is to study genome aging [6] and its recovery. Here we can use the method and formalism of our statistical and kinetic approach. It makes sense to assess changes in the statistical entropy of arterial and venous blood for a separate organ. To solve such problems, you can use the concepts developed in our works [3-5]. Concepts of statistical entropy also make it possible to develop models that describe the formation of beta-amyloid plaques [7]. 1. Schrodinger, Erwin (2012). What is life?: the physical aspect of the living cell ; with, Mind and matter ; & Autobiographical sketches. New York: Cambridge University Press. Edited by Erwin Schrödinger. 2. Blumenfeld L. Problems of biophysics. M.: Nauka. 1984. 3. Aristov V.V., Karnaukhov A.V., Levchenko V.F., Nechipurenko Yu.D. Entropy and information in the description of biosystems // Biophysics. 2022, volume 67, no. 4, p. 1–8. 4. Aristov V.V. Biological systems as nonequilibrium structures described by kinetic methods // Results in Physics. 2019. V. 13. 102232. 5. Aristov V. V., Karnaukhov A. V., Buchelnikov A. S., Levchenko V. F., Nechipurenko Y. D. The Degradation and Aging of Biological Systems as a Process of Information Loss and Entropy Increase // Entropy. 2023, 25, 1067. 6. Karnaukhov A.V. and others. Information theory of aging: the main factors that determine life expectancy // Biophysics. 2017. T. 62, v. 5, p. 1008–1015. 7. Vasilenko E.O., Kozin S.A., Mitkevich V.A., Buchelnikov A.S., Nechipurenko Yu.D. Thermodynamic model of the formation of protein aggregates on a matrix. Biophysics, 2024, in press.
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